en_tn/pro/01/28.md

Then they will call upon me

"Then the sinners will cry out to me, wisdom, for help"

desperately

with much worry and little hope

Because they hate knowledge...they despised all my reproof

Possible meanings: 1) This is why they will "eat the fruit of their ways" (Proverbs 1:31) (see UDB) or 2) this is why wisdom "will not answer" (1:28) or 3) 1:29 gives the reason for 1:30.

despised

Translate as you did in Proverbs 1:7