antichrist, antichrists

Definition:

The term "antichrist" refers to a person or teaching that is against Jesus Christ and his work. There are many antichrists in the world.

The apostle John wrote that a person is the antichrist if he deceives people by saying that Jesus is not the Messiah or if he denies that Jesus is both God and human.
The Bible also teaches that there is a general spirit of antichrist in the world which opposes Jesus' work.
The New Testament book of Revelation explains that there will be a man called "the antichrist" who will be revealed in the end times. This man will attempt to destroy God's people, but he will be defeated by Jesus.

Other ways to translate this term could include a word or phrase that means "Christ-opposer" or "enemy of Christ" or "person who is against Christ."
The phrase "spirit of the antichrist" could also be translated as "spirit that is against Christ" or "(someone) teaching lies about Christ" or "attitude of believing lies about Christ" or "spirit that teaches lies about Christ."
Also consider how this term is translated in a Bible translation in a local or national language. (See: How to Translate Unknowns)