God said to him
"God said to Jacob"
Be fruitful and multiply
God told Jacob to produce children so that there would be many of them. The word "multiply" explains how he was to be "fruitful." See how you translated this in Genesis 1:22. (See: rc://en/ta/man/translate/figs-doublet and rc://en/ta/man/translate/figs-idiom)
A nation and a company of nations will come from you
Here "nation" and "nations" refer to Jacob's descendants who will establish these nations. (See: rc://en/ta/man/translate/figs-metonymy)
God went up from him
Here "went up" is used because where God dwells is typically thought of as being up or above the world. AT: "God left him"